RNA Details
Disease Name
pulmonary hypertension
Tissue
lung
RNA Symbol
mir-451
RNA ID
RNA Type
miRNA
Alteration Pattern
up regulation
Species
rattus norvegicus
Detection Methods
HPASMCS; Gene targets for miR-451; miRNA expression etc.
Target
NA
Pathway
NA
PubMed ID
Title
Transient but not genetic loss of miR-451 is protective in the development of pulmonary arterial hypertension
Year
2013
Function
"Transient inhibition of miR-451 attenuated the development of PAH in hypoxia-exposed rats. Genetic deletion of miR-451 had no beneficial effect on indices of PAH, potentially because of pathway redundancy compensating for the loss of miR-451."